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1

Functional characterization of p53 pathway components in the ancient metazoan Trichoplax adhaerens

Siau, Jia Wei, Coffill, Cynthia R., Zhang, Weiyun Villien, Tan, Yaw Sing, Hundt, Juliane, Lane, David, Verma, Chandra, Ghadessy, Farid

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 1.40 MB

english, 2016

2

Compartmentalized linkage of genes encoding interacting protein pairs

Saurabh R. Nirantar, Farid J. Ghadessy

Journal:

Year:

2011

Language:

english

File:

PDF, 286 KB

english, 2011

3

Generic expansion of the substrate spectrum of a DNA polymerase by directed evolution

Ghadessy, Farid J, Ramsay, Nicola, Boudsocq, François, Loakes, David, Brown, Anthony, Iwai, Shigenori, Vaisman, Alexandra, Woodgate, Roger, Holliger, Philipp

Journal:

Nature Biotechnology

Year:

2004

Language:

english

File:

PDF, 543 KB

english, 2004

4

Analysis of p53 binding to DNA by fluorescence imaging microscopy

Hwee Jing Ong, Jia Wei Siau, Jing Bo Zhang, Minghui Hong, Horst Flotow, Farid Ghadessy

Journal:

Year:

2012

Language:

english

File:

PDF, 654 KB

english, 2012

5

Directed Evolution of p53 Variants with Altered DNA-binding Specificities by In Vitro Compartmentalization

Chen Xue Fen, David W. Coomber, David P. Lane, Farid J. Ghadessy

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 894 KB

english, 2007

6

A novel splice site mutation in the androgen receptor gene results in exon skipping and a non-functional truncated protein

Joyce Lim, Farid J Ghadessy, E.L Yong

Journal:

Molecular and Cellular Endocrinology

Year:

1997

Language:

english

File:

PDF, 193 KB

english, 1997

7

Binding of Translationally Controlled Tumour Protein to the N-Terminal Domain of HDM2 Is Inhibited by Nutlin-3

Funston, Garth, Goh, Walter, Wei, Siau Jia, Tng, Quah Soo, Brown, Christopher, Jiah Tong, Loh, Verma, Chandra, Lane, David, Ghadessy, Farid, Maki, Carl G.

Journal:

Year:

2012

Language:

english

File:

PDF, 401 KB

english, 2012

8

A generic scaffold for conversion of peptide ligands into homogenous biosensors

Nirantar, Saurabh R., Yeo, Kun Song, Chee, Sharon, Lane, David P., Ghadessy, Farid J.

Journal:

Biosensors and Bioelectronics

Year:

2013

Language:

english

File:

PDF, 3.01 MB

english, 2013

9

Rapid screening of protein–protein interaction inhibitors using the protease exclusion assay

Nirantar, Saurabh R., Li, Xiang, Siau, Jia Wei, Ghadessy, Farid J.

Journal:

Biosensors and Bioelectronics

Year:

2014

Language:

english

File:

PDF, 2.95 MB

english, 2014

10

Molecular Rotors As Conditionally Fluorescent Labels for Rapid Detection of Biomolecular Interactions

Goh, Walter L., Lee, Min Yen, Joseph, Thomas L., Quah, Soo Tng, Brown, Christopher J., Verma, Chandra, Brenner, Sydney, Ghadessy, Farid J., Teo, Yin Nah

Journal:

Journal of the American Chemical Society

Year:

2014

Language:

english

File:

PDF, 1.22 MB

english, 2014

11

Long Polyglutamine Tracts in the Androgen Receptor Are Associated with Reduced Trans -Activation, Impaired Sperm Production, and Male Infertility 1

Tut, Thein G., Ghadessy, Farid J., Trifiro, M. A., Pinsky, L., Yong, E. L.

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

1997

Language:

english

File:

PDF, 970 KB

english, 1997

12

Rapid and sensitive detection of acrylic acid using a novel fluorescence assay

Lee, Zhi Yi, Raghavan, Sarada S., Ghadessy, Farid J., Teo, Yin Nah

Journal:

Year:

2014

Language:

english

File:

PDF, 1.18 MB

english, 2014

13

A highly sensitive fluorescent light-up probe for real-time detection of the endogenous protein target and its antagonism in live cells

Geng, Junlong, Goh, Walter L., Zhang, Chongjing, Lane, David P., Liu, Bin, Ghadessy, Farid, Tan, Yen Nee

Journal:

Journal of Materials Chemistry B

Year:

2015

Language:

english

File:

PDF, 1.20 MB

english, 2015

14

Development of a novel multiplex in vitro binding assay to profile p53-DNA interactions

Goh, Walter, Lane, David, Ghadessy, Farid

Journal:

Year:

2010

Language:

english

File:

PDF, 1.20 MB

english, 2010

15

Human Androgen Receptor Mutation Disrupts Ternary Interactions between Ligand, Receptor Domains, and the Coactivator TIF2 (Transcription Intermediary Factor 2)

Lim, Joyce, Ghadessy, Farid J., Abdullah, Abdullah A. R., Pinsky, Leonard, Trifiro, Mark, Yong, E. L.

Journal:

Molecular Endocrinology

Year:

2000

Language:

english

File:

PDF, 250 KB

english, 2000

16

The Mdm2 and p53 genes are conserved in the Arachnids

Lane, David P., Cheok, Chit Fang, Brown, Christopher J., Madhumalar, Arumugam, Ghadessy, Farid J., Verma, Chandra

Journal:

Year:

2010

Language:

english

File:

PDF, 1.82 MB

english, 2010

17

Azoospermia Associated with a Mutation in the Ligand-Binding Domain of an Androgen Receptor Displaying Normal Ligand Binding, but Defective Trans -Activation 1

Wang, Qi, Ghadessy, Farid J., Trounson, Alan, de Kretser, David, McLachlan, Rob, Ng, s. C., Yong, E. L.

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

1998

Language:

english

File:

PDF, 404 KB

english, 1998

18

CELL-FREE SELECTION OF DNA-BINDING PROTEINS FOR FUTURE GENE THERAPY APPLICATIONS

SEPP, ARMIN, GHADESSY, FARID, CHOO, YEN

Journal:

Gene Therapy and Regulation

Year:

2007

Language:

english

File:

PDF, 434 KB

english, 2007

19

Conservative site-specific and single-copy transgenesis in human LINE-1 elements

Vijaya Chandra, Shree Harsha, Makhija, Harshyaa, Peter, Sabrina, Myint Wai, Cho Mar, Li, Jinming, Zhu, Jindong, Ren, Zhonglu, D'Alcontres, Martina Stagno, Siau, Jia Wei, Chee, Sharon, Ghadessy, Farid

Journal:

Nucleic Acids Research

Year:

2015

Language:

english

File:

PDF, 7.55 MB

english, 2015

20

Enhanced antigen detection in immunohistochemical staining using a ‘digitized’ chimeric antibody

Eng, Hui-Yan, Wang, Cheng-I, Xue, Yuezhen, Lee, Chia-Yin, Binte Zulkifli, Sarah, Chiam, Poh-Cheang, Ghadessy, Farid J., Lane, David P.

Journal:

Protein Engineering Design and Selection

Year:

2015

Language:

english

File:

PDF, 1.30 MB

english, 2015

21

Mdm2 and p53 are highly conserved from placozoans to man

Lane, David P., Cheok, Chit Fang, Brown, Christopher, Madhumalar, Arumugam, Ghadessy, Farid J., Verma, Chandra

Journal:

Year:

2010

Language:

english

File:

PDF, 1.87 MB

english, 2010

22

Detection of the 113p53 protein isoform: A p53-induced protein that feeds back on the p53 pathway to modulate the p53 response in zebrafish

Guo, Lin, Chua, Joy, Vijayakumar, Danesh, Lee, Kian Chung, Lim, Kathy, Eng, Huiyan, Ghadessy, Farid, Coomber, David, Lane, David P.

Journal:

Year:

2010

Language:

english

File:

PDF, 4.41 MB

english, 2010

23

The p53–Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans

Coffill, Cynthia R., Lee, Alison P., Siau, Jia Wei, Chee, Sharon M., Joseph, Thomas L., Tan, Yaw Sing, Madhumalar, Arumugam, Tay, Boon-Hui, Brenner, Sydney, Verma, Chandra S., Ghadessy, Farid J., Venk

Journal:

Genes & Development

Year:

2016

Language:

english

File:

PDF, 1.33 MB

english, 2016

24

Going native: Complete removal of protein purification affinity tags by simple modification of existing tags and proteases

Goh, Hui Chin, Sobota, Radoslaw M., Ghadessy, Farid J., Nirantar, Saurabh

Journal:

Protein Expression and Purification

Year:

2017

Language:

english

File:

PDF, 1.36 MB

english, 2017

25

Development of a genetically programed vanillin-sensing bacterium for high-throughput screening of lignin-degrading enzyme libraries

Sana, Barindra, Chia, Kuan Hui Burton, Raghavan, Sarada S., Ramalingam, Balamurugan, Nagarajan, Niranjan, Seayad, Jayasree, Ghadessy, Farid J.

Journal:

Biotechnology for Biofuels

Year:

2017

Language:

english

File:

PDF, 3.84 MB

english, 2017

26

Laccase-catalyzed synthesis of low molecular weight lignin-like oligomers and their application as UV blocking materials

Ramalingam, Balamurugan, Lim, Jieyan, Krishnan, Ranganathan, Seayad, Jayasree, Sana, Barindra, Ghadessy, Farid John, Jana, Satyasankar

Journal:

Chemistry – An Asian Journal

Year:

2017

Language:

english

File:

PDF, 1.43 MB

english, 2017

27

Laccase-Catalyzed Synthesis of Low-Molecular-Weight Lignin-Like Oligomers and Their Application as UV-Blocking Materials

Lim, Jieyan, Sana, Barindra, Krishnan, Ranganathan, Seayad, Jayasree, Ghadessy, Farid J., Jana, Satyasankar, Ramalingam, Balamurugan

Journal:

Chemistry – An Asian Journal

Year:

2018

Language:

english

File:

PDF, 2.51 MB

english, 2018

28

Anatomy of Mdm2 and Mdm4 in evolution

Tan, Ban Xiong, Liew, Hoe Peng, Chua, Joy S., Ghadessy, Farid J., Tan, Yaw Sing, Lane, David P., Coffill, Cynthia R.

Journal:

Journal of Molecular Cell Biology

Year:

2017

Language:

english

File:

PDF, 1.53 MB

english, 2017

29

Rapid colorimetric detection of p53 protein function using DNA-gold nanoconjugates with applications for drug discovery and cancer diagnostics

Assah, Enock, Goh, Walter, Zheng, Xin Ting, Lim, Ting Xiang, Li, Jun, Lane, David, Ghadessy, Farid, Tan, Yen Nee

Journal:

Colloids and Surfaces B: Biointerfaces

Year:

2018

Language:

english

File:

PDF, 577 KB

english, 2018

30

Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids

Chee, Sharon Min Qi, Wongsantichon, Jantana, Siau, Jiawei, Thean, Dawn, Ferrer, Fernando, Robinson, Robert C., Lane, David P., Brown, Christopher J., Ghadessy, Farid J., Fernandez-Fuentes, Narcis

Journal:

Year:

2017

Language:

english

File:

PDF, 5.25 MB

english, 2017

31

In Vitro Selection of Mutant HDM2 Resistant to Nutlin Inhibition

Wei, Siau Jia, Joseph, Thomas, Sim, Adelene Y. L., Yurlova, Larisa, Zolghadr, Kourosh, Lane, David, Verma, Chandra, Ghadessy, Farid, Maki, Carl G.

Journal:

Year:

2013

Language:

english

File:

PDF, 2.60 MB

english, 2013

32

Inhibition of Nutlin-Resistant HDM2 Mutants by Stapled Peptides

Wei, Siau Jia, Joseph, Thomas, Chee, Sharon, Li, Ling, Yurlova, Larisa, Zolghadr, Kourosh, Brown, Christopher, Lane, David, Verma, Chandra, Ghadessy, Farid, Fei, Peiwen

Journal:

Year:

2013

Language:

english

File:

PDF, 2.70 MB

english, 2013

33

A novel molecular rotor facilitates detection of p53-DNA interactions using the Fluorescent Intercalator Displacement Assay

Goh, Walter L., Lee, Min Yen, Lim, Ting Xiang, Chua, Joy S., Brenner, Sydney, Ghadessy, Farid J., Teo, Yin Nah

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 3.53 MB

english, 2018

34

A novel λ integrase-mediated seamless vector transgenesis platform for therapeutic protein expression

Makhija, Harshyaa, Roy, Suki, Hoon, Shawn, Ghadessy, Farid John, Wong, Desmond, Jaiswal, Rahul, Campana, Dario, Dröge, Peter

Journal:

Nucleic Acids Research

Year:

2018

Language:

english

File:

PDF, 3.48 MB

english, 2018

35

Ultrasensitive dynamic light scattering based nanobiosensor for rapid anticancer drug screening

Zheng, Xin Ting, Goh, Walter L., Yeow, Peter, Lane, David P., Ghadessy, Farid J., Tan, Yen Nee

Journal:

Sensors and Actuators B: Chemical

Year:

2019

Language:

english

File:

PDF, 756 KB

english, 2019

36

Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket

Pradhan, Mohan R, Siau, Jia Wei, Kannan, Srinivasaraghavan, Nguyen, Minh N, Ouaray, Zohra, Kwoh, Chee Keong, Lane, David P, Ghadessy, Farid, Verma, Chandra S

Journal:

Nucleic Acids Research

Year:

2019

Language:

english

File:

PDF, 4.73 MB

english, 2019

37

Development and structural characterization of an engineered multi-copper oxidase reporter of protein-protein interactions

Sana, Barindra, Chee, Sharon Min Qi, Wongsantichon, Jantana, Raghavan, Sarada, Robinson, Robert C., Ghadessy, Farid J.

Journal:

Journal of Biological Chemistry

Year:

2019

File:

PDF, 6.55 MB

2019

38

Development and structural characterization of an engineered multi-copper oxidase reporter of protein-protein interactions

Sana, Barindra, Chee, Sharon Min Qi, Wongsantichon, Jantana, Raghavan, Sarada, Robinson, Robert C., Ghadessy, Farid J.

Journal:

Journal of Biological Chemistry

Year:

2019

Language:

english

File:

PDF, 6.55 MB

english, 2019

39

Bortezomib Stabilizes and Activates p53 in Proliferative Compartments of both Normal and Tumor Tissues In Vivo

Xue, Yuezhen, Barker, Nick, Hoon, Shawn, He, Pingping, Thakur, Teena, Abdeen, Shifana Raja, Maruthappan, Priadarsini, Ghadessy, Farid J, Lane, David P

Journal:

Cancer Research

Year:

2019

Language:

english

File:

PDF, 2.68 MB

english, 2019

40

Development and application of a transcriptional sensor for detection of heterologous acrylic acid production in E. coli

Raghavan, Sarada S., Chee, Sharon, Li, Juntao, Poschmann, Jeremie, Nagarajan, Niranjan, Jia Wei, Siau, Verma, Chandra S., Ghadessy, Farid J.

Journal:

Microbial Cell Factories

Year:

2019

Language:

english

File:

PDF, 3.57 MB

english, 2019

41

Transmembrane signaling on a protocell: Creation of receptor-enzyme chimeras for immunodetection of specific antibodies and antigens

Su, Jiulong, Kitaguchi, Tetsuya, Ohmuro-Matsuyama, Yuki, Seah, Theresa, Ghadessy, Farid J., Hoon, Shawn, Ueda, Hiroshi

Journal:

Scientific Reports

Year:

2019

File:

PDF, 2.38 MB

2019

42

Directed co-evolution of interacting proteinâpeptide pairs by compartmentalized two-hybrid replication (C2HR)

Siau, JiaÂ Wei, Nonis, Samuel, Chee, Sharon, Koh, LiÂ Quan, Ferrer, Fernando J, Brown, ChristopherÂ J, Ghadessy, Farid J

Journal:

Nucleic Acids Research

Year:

2020

File:

PDF, 5.29 MB

2020

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